A case of multiple epiphyseal dysplasia.

Multiple epiphyseal dysplasia

BACKGROUND Multiple epiphyseal dysplasia (MED) is a common genetically and clinically heterogeneous skeletal dysplasia characterized by early-onset osteoarthritis, mainly in the hip and knee, and mild-to-moderate short stature. Here we report on a 6-generation MED family with 17 affected members. METHOD The clinical and radiographic data on the 12 affected members still living were scrutinize...

Multiple epiphyseal dysplasia.

Fig. 5 : x-ray hand showing bilateral small fifth metacarpals, small right fourth metacarpal, and degeneration of distal epiphysis and interphalangeal joints Fig. 6 : Foot x-ray showing degenerated joints, shortening of fourth and fifth metatarsals with degenerated distal epiphysis Fig. 7 : MRI showing degenerative disc disease with spinal cord compression involving cervical, lumber and dorsal ...

Perthes' disease and multiple epiphyseal dysplasia.

Five atypical cases were observed amongst ninety children with Perthes' disease, ten of whom had bilateral hip joint involvement. All five were boys, four being under 4 years of age. Four had bilateral hip joint disease, four presented with hip pain, three showing some degree of retardation of bone growth. In one case the hip disorder was familial, and in four there were bony abnormalities else...

A mutation in COL9A2 causes multiple epiphyseal dysplasia (EDM2).

Multiple epiphyseal dysplasia in children: beware of overtreatment!

PURPOSE To determine the various musculoskeletal manifestations of multiple epiphyseal dysplasia in children, and the course of this disease in childhood. METHODS Ten children were diagnosed and treated at the Children's Hospital of Eastern Ontario (CHEO) for multiple epiphyseal dysplasia, 1976-2001. We reviewed the clinical, pathological and radiographic records for these cases to determine ...